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Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome | L. Collado-Torres

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Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome | L. Collado-Torres Toggle navigation L. Collado-Torres Home Publications Talks Blog CV Students Teaching Contact Search Developmental effects of maternal smoking during pregnancy on the human frontal cortex transcriptome Semick SA, Collado-Torres L, Markunas CA, Shin JH, Deep-Soboslay A, Tao R, Huestis MA, Bierut LJ, Maher BS, Johnson EO, Hyde TM, Weinberger DR, Hancock DB, Kleinman JE †, Jaffe AE † Abstract Cigarette smoking during pregnancy is a major public health concern. While there are well-described consequences in early child development, there is very little known well-nigh the effects of maternal smoking on human cortical biology during prenatal life. We therefore performed a genome-wide differential gene expression wringer using RNA sequencing (RNA-seq) on prenatal (N = 33; 16 smoking-exposed) as well as sultana (N = 207; 57 zippy smokers) human postmortem prefrontal cortices. Smoking exposure during the prenatal period was directly associated with differential expression of 14 genes; in contrast, during adulthood, despite a much larger sample size, only two genes showed significant differential expression (FDR < 10%). Moreover, 1,315 genes showed significantly variegated exposure effects between maternal smoking during pregnancy and uncontrived exposure in womanhood (FDR < 10%)—these differences were largely driven by prenatal differences that were enriched for pathways previously implicated in tendency and synaptic function. Furthermore, prenatal and age-dependent differentially expressed genes were enriched for genes implicated in non-syndromic autism spectrum disorder (ASD) and were differentially expressed as a set between patients with ASD and controls in postmortem cortical regions. These results underscore the enhanced sensitivity to the biological effect of smoking exposure in the developing smart-ass and offer insight into how maternal smoking during pregnancy affects gene expression in the prenatal human cortex. They moreover uncork to write the relationship between in utero exposure to smoking and the heightened risks for the subsequent minutiae of neuropsychiatric disorders. Type Peer-reviewed Publication Molecular Psychiatry Date August, 2018 Links PDF Code Pre-print Read for self-ruling © 2011-2018 Leonardo Collado Torres under (CC) BY-NC-SA 4.0. All thoughts and opinions here are my own. · Powered by the Academic theme for Hugo. × Cite Copy Download